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Propecia
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The marketing clearance of Propecia is based on data from three one-year, double-blind, placebo-controlled, multicenter clinical trials involving 1,879 men aged 18 to 41 with mild to
moderate hair loss of the vertex and anterior mid-scalp areas. In addition, 1,215 of the men who had hair loss at the vertex, or top of the head, were studied for another year.
Hair count increased during the first year and was maintained in those men taking Propecia for 24 months; men in the placebo group continued to show progressive hair loss. In an analysis of the men who were followed for up to two years, only 17 percent of men treated with Propecia demonstrated hair loss (defined as any decrease in hair count from baseline); 83 percent had the same or higher hair count. In contrast, 72 percent of the placebo group lost hair, as measured by hair count. Through questionnaires, all patients were asked to evaluate their response to treatment. Those on Propecia reported an increase in the amount of hair, a decrease in hair loss, and improvement in appearance. Clinical improvement was seen as early as three months.
In another analysis, a panel of independent dermatologists evaluated photos in 508 patients after 24 months of treatment. An increase in hair growth was demonstrated in 66 percent of men treated with Propecia compared to 7 percent of men treated with placebo. Efficacy in bitemporal recession has
not been established. All men, whether receiving Propecia or placebo, were given a medicated shampoo (Neutrogena T/Gel Shampoo).
``Propecia works by inhibiting the conversion of testosterone to DHT (dihydro-testosterone),'' said Keith Kaufman, M.D., senior director, Clinical Research, Merck Research Laboratories in Rahway, N.J. ``It is the first treatment to target this key factor in the development of androgenetic alopecia in
those patients genetically predisposed.''
Cautionary Information for Women
Propecia is for use by men only. It is not for use in women or children. Women must not use Propecia when they are or may potentially be pregnant because it may cause abnormalities of the male baby's sex organs, a condition known as hypospadias. In addition, women should not handle crushed or broken tablets when they are pregnant or may potentially be pregnant. Propecia tablets have a coating that will prevent contact with the active ingredient during normal handling, provided that the tablets have not been broken or crushed.
Side Effects: Uncommon
In clinical studies, side effects were uncommon and did not affect most men. A small number of men reported less desire for sex, difficulty in achieving an erection and/or a decrease in the amount of semen. Each of these effects occurred in less than 2 percent of men. These side effects went away in all men who discontinued therapy because of them and also disappeared in 58 percent of men who chose to continue taking Propecia.
Merck's catalog price to wholesalers and direct purchasers for Propecia will be $1.25 per tablet. Merck estimates that the retail price for Propecia will be between $45 to $49 per month, based on historical markups at the retail level. Prices at the retail level are established by pharmacies, not by Merck, and can vary. Propecia will be available in bottles of 30 and in special ProPak(TM) convenience packages that feature a three-month supply, a $10 patient rebate and an informational
patient brochure.
Merck & Co., Inc. is a leading research-driven pharmaceutical products and services company. Merck discovers, develops and markets a broad range of innovative products to improve human health and quality of life.
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Rogaine
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Rogaine Extra Strength contains 5% Minoxidil, the only FDA approved topical treatment for hair loss. In clinical studies, four out of five users claimed Rogaine helped slow or stop their hair loss. Rogaine Extra Strength has 45% more regrowth than regular strength. This means that there is enhanced penetration of the hairs follicle and significantly more hair growth - results may occur in as soon as 2 months.
Rogaine is a topical liquid, not a systemic medication. That means it’s applied to the top of your scalp, instead of taken internally. You'll be relieved to know that Men's Rogaine Extra Strength works without altering male hormones.
A small percentage of users, about 6%, experience scalp irritation.
Rogaine is applied directly to the scalp in the hair loss area twice daily; for example, once in the morning and once at night. The night-time application should occur 2-4 hours before bed to allow for drying. Each bottle should last about 25-30 days, if used as directed. Hair can be styled normally after the Rogaine had dried. The twinpack contains 2 month's supply of Rogaine
Rogaine Extra Strength is not for use by women
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Rogaine For Women
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Rogaine for Women Hair Regrowth Treatment - Rogaine contains 2% Minoxidil, the only FDA approved treatment for hair loss. In clinical studies, four out of five users claimed Rogaine helped slow or stop their hair loss.
Rogaine is applied directly to the scalp in the hair loss area twice daily; for example, once in the morning and once at night. The night-time application should occur 2-4 hours before bed to allow for drying. Each bottle should last about 25-30 days, if used as directed. Hair can be styled normally after the Rogaine had dried.
Since normal hair grows only 1/2 to 1 inch per month, hair regrowth with Rogaine takes some time. Continued use of Rogaine twice a day for at least four months is usually needed before you notice hair regrowth. You will need to continue use of Rogaine to maintain the hair regrowth.
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Tricomin Product Line
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Using an FDA clinically tested method, Tricomin products showed effectiveness in stimulating hair growth in partial FDA Trials.
Therapy Spray: Designed for men and women with thinning hair, the Therapy Spray combines the benefits of clinically-tested Triamino Copper Nutritional Complex™ with an exceptional leave-in conditioner formulation. The Therapy Spray enriches your hair and scalp with a unique blend of essential amino acids, minerals and body-building ingredients. Condition and treat your hair and scalp daily by spraying liberally after shampooing. Should be applied to damp or dry hair.
Shampoo: Combines a unique cleansing and body building formulation to bathe your scalp with essential amino acids and minerals. Revitalizing Shampoo stimulates and restores health, structure, and vitality to thinning, fine, or damaged hair.
Conditioner: Using a unique moisture and nutrient-rich framework, Restructuring Conditioner helps restore your hair's natural protein and mineral balance, building structure, luster, and body onto thinning, damaged and otherwise challenged hair.
This product is recommended as an adjunct to clinically proven treatments like Propecia (men only) and Rogaine. It is in the group of treatments considered growth stimulants and it complements Rogaine well by stimulating hair growth in a separate but complementary way.
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Q: Did you know that your body and your hair require copper to be at their best?
A: It’s true – and scientifically proven!! Development of the Tricomin line of hair care products evolved from years of research involving copper and amino acids. Copper is linked to these important biological processes critical to the health of your skin and hair:
- Melanin production (pigmentation)
- Energy metabolism
- Scavenging of damaging free radicals
- Crosslinking of collagen and elastin
- Inhibition of 5-alpha reductase (the enzyme that reduces testosterone to DHT – its active metabolite reponsible for androgenetic alopecia)
Q: Did you know that your hair is relatively rich in copper?
A: Also true. Compared to most other parts of your body, your hair has a natural affinity for copper. Interestingly enough, copper levels in the body tend to decrease as you get older, just at the time when you may need it the most!
Q: Did you realize that your hair follicles cycle between growth periods and resting periods?
A: Again true! In fact, hair thinning and loss can result from changes in the hair cycle resulting in a process known as miniaturization.
The Tricomin story!!
Studies have demonstrated the positive effects of Triamino Copper Nutritional Complex™ on hair follicles! During the growth phase, the base of the hair follicle (dermal papilla) is richly endowed with substances such as collagen and various proteins. These substances are virtually absent during the resting phase. Copper has been shown to stimulate the cells responsible for production of these substances! As shown, Tricomin products target delivery of copper to the base of the follicle.
The Tricomin Advantage
In addition to the science of copper, other components of the Tricomin products (such as panthenol) add desirable structural qualities to the hair, building body and adding shine. While Tricomin’s cosmetic benefits will be realized in the short-term, the added benefits of the Triamino Copper Nutritional Complex™ may require longer term use.
As the centerpiece of the product line, Tricomin Solution – Follicle Therapy Spray combines the highest concentration of copper peptide with an excellent leave-in conditioner framework. Tricomin products can be used effectively with other hair treatments including Rogaine™ and Propecia™, providing additional benefit to the hair follicle and surrounding environment
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